Electrophysiology-guided brain stimulation for psychiatric disorders

Abstract While TMS represents an exciting treatment tool for psychiatry, clinical response depression is <50%. Furthermore, <1% of available protocols (frequency, amplitude, pattern, etc) are utilized clinically. The low rate and under-utilization novel patterns partially because we lack a mechanistic understanding the circuit-level neuromodulatory changes induced by TMS. This impedes optimization driven fact that do not have robust reproducible methodology to measure brain in real-time clinic. Combining EEG (TMS-EEG) boosting its signal-to-noise represent promising clinic-ready noninvasive help optimize In this talk, first present work utilizes TMS-EEG identify ‘p30,’ biomarker after relates outcome. Interestingly p30 another study also observed intracranially using electrical stimulation perceived patients. Next ongoing methodological efforts lab increase reliability validity biomarker. Finally, briefly discuss recent explore how differentially modulate Enhancing exploring parameter space critical steps development adaptive closed-loop protocols. Research Category Technology Methods Clinical Research: 10. Transcranial Magnetic Stimulation (TMS) Keywords: TMS, EEG, Electrophysiology, Depression