Electrophilic substitution. II. Friedel-Crafts type nitration using acetone cyanohydrin nitrate

Friedel-Crafts alkylation of Phenol using Ionic Liquid as Catalyst

Biocatalytic Friedel-Crafts alkylation using non-natural cofactors.

The formation of C C bonds is a central aspect of synthetic organic chemistry. However, in biocatalysis only few enzymes capable to perform this reaction are known, among which aldolases, transketolases, and hydroxynitril lyases have been investigated thoroughly. Some have even found their way into industrial applications. Friedel–Crafts alkylation is a classic organic reaction of great importa...

Biocatalytic Friedel–Crafts Acylation and Fries Reaction

The Friedel-Crafts acylation is commonly used for the synthesis of aryl ketones, and a biocatalytic version, which may benefit from the chemo- and regioselectivity of enzymes, has not yet been introduced. Described here is a bacterial acyltransferase which can catalyze Friedel-Crafts C-acylation of phenolic substrates in buffer without the need of CoA-activated reagents. Conversions reach up to...

Friedel-Crafts alkylation of indoles with epoxides using PW12-APTES@SBA-15

H3PW12O40 (PW12) was immobilized over mesoporous alumina through the reaction of mesoporous alumina functionalized 3-aminopropyl triethoxy silane (3-APTES) and PW12. The surface properties of the functionalized nanocomposite was analyzed by a series of characterization techniques like elemental analysis, FTIR and XRD. XRD and adsorption–desorption analysis shows that the mesostructure of silica...

Enantioselective Friedel-Crafts alkylation of pyrroles catalyzed by PYBOX-DIPH-Zn(II) complexes.

A highly enantioselective Friedel-Crafts alkylation of pyrroles with 2-enoylpyridine N-oxides catalyzed by chiral PYBOX-DIPH-Zn(II) complexes has been developed. The catalyst offers substantial substrate scope and furnished alkylated pyrroles in excellent yields (up to 99%) and enantioselectivities (up to >99% ee).