Electroosmosis Based Novel Treatment Approach for Cerebral Edema

Objective: Cerebral edema characterized as an abnormal accumulation of interstitial fluid has not been treated effectively. We propose a novel treatment approach to drive edematous out the brain by direct current utilizing tissue's electroosmotic property. Methods: A finite element (FE) head model is developed and employed assess feasibility approach. First, capacity for electric field prediction validated against human experiments. Second, two electrode configurations (S D-montage) are designed evaluate distribution field, flow (EOF), density, temperature across under applied current. Results: The S-montage shown induce average EOF velocity 7e-4 mm/s underneath anode voltage 15 V, D-montage induces 9e-4 5 V. Meanwhile, in both below 38 °C, which within safety range. Further, magnitude proportional direction follows from cathode. white matter significantly higher than that gray where be drawn out. Conclusion: proposed electroosmosis based allows alleviating critical time window Significance: may further new solely or complement existing conventional treatments edema.