ELAM-1/E-selectin promoter contains an inducible AP-1/CREB site and is not NF-κB-specific
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چکیده
منابع مشابه
Resveratrol suppresses hyperglycemia-induced activation of NF-κB and AP-1 via c-Jun and RelA gene regulation
Background: Resveratrol (RSV) provides several important biological functions in wide variety of cells. In this study, we investigated the molecular mechanisms underlying anti-inflammatory effect of RSV on HepG2 cells by assessing the gene expression of RelA and c-Jun- subunits of NF-κB and AP-1 transcription factors. Methods: HepG2 cells were settled in a serum- free medium...
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Transcriptional regulation of the interferon-β (IFN-β) gene is characterized by strict constitutive repression and virus-specific activation. Previous studies have shown that the IFN-β promoter is constitutively repressed by a negative regulatory element (NRE). Isolated NRE acts as a constitutive and positionindependent silencer on the NF-κB-binding sites. Here, we describe the identification a...
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Most K-Cl cotransport in the erythrocyte is attributed to potassium chloride cotransporter 1 (KCC1). K-Cl cotransport is elevated in sickle erythrocytes, and the KCC1 gene has been proposed as a modifier gene in sickle cell disease. To provide insight into our understanding of the regulation of the human KCC1 gene, we mapped the 5' end of the KCC1 cDNA, cloned the corresponding genomic DNA, and...
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ژورنال
عنوان ژورنال: BioTechniques
سال: 2003
ISSN: 0736-6205,1940-9818
DOI: 10.2144/03351bm05