Ehrlich tumor inhibition using doxorubicin containing liposomes
نویسندگان
چکیده
منابع مشابه
Antivasculature effects of doxorubicin-containing liposomes in an intracranial rat brain tumor model.
Increased neovascularization and vascular hyperpermeability are integral processes in tumors, and various therapeutic strategies seek to reverse the angiogenic phenotype. Long-circulating liposomes extravasate in tumors such as the rat 9L gliosarcoma and accumulate in perivascular areas. Under such conditions, liposome-encapsulated doxorubicin (DOX) provides approximately 30% increase in life s...
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The ability of liposomes containing a synthetic lipophilic muramyl dipeptide derivative, N-acetylmuramyl-L-alanyl-D-isoglutamyl-sn-glycerol dipalmitate (MDP-GDP), to inhibit the growth of experimental B16-F1 melanoma liver metastases in syngeneic C57BL/6 mice has been determined. Multiple i.v. injections of distearoylphosphatidylcholine:dimyristoylphosphatidylglycerol liposomes (1 mumol, 10:1 m...
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PURPOSE The incorporation of doxorubicin in long-circulating sterically stabilized liposomes (SSL-DXR) alters the pharmacokinetics and biodistribution of doxorubicin and therefore has the potential to alter the pharmacologic properties of doxorubicin. Previously, we showed that repetitive administration of SSL-DXR alters tumor vascular permeability. EXPERIMENTAL DESIGN Here, we investigated t...
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The effect of changes in lipid composition on the antitumor activity of doxorubicin (DXR)-containing liposomes was studied in immunoglobulin solid immunocytoma-bearing Lou/M Wsl rats. Rats bearing a tumor with a diameter between 20 and 30 mm were treated i.v. with 2 mg/kg free DXR or different DXR-containing liposome types for 5 consecutive days followed by one injection more at day 11 after st...
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oncogenic RNA viruses. It has also been reported (24) that single-stranded polyribonucleotides at very low concentrations inhibit DNA polymerase of Rauscher leukemia virus. In this report, we present data that show a way in which RNA indirectly affects DNA synthesis. These data show that RNA markedly inhibits ribonucleotide reducÃ-asefrom Ehrlich ascites tumor cells, at concentrations which cou...
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ژورنال
عنوان ژورنال: Saudi Pharmaceutical Journal
سال: 2015
ISSN: 1319-0164
DOI: 10.1016/j.jsps.2014.07.003