Efomycine M: an inhibitor of selectins?
نویسندگان
چکیده
منابع مشابه
Diminished lymphocyte adhesion and alleviation of allergic responses by small-molecule- or antibody-mediated inhibition of L-selectin functions.
Selectins are attractive targets for specific anti-inflammatory therapies. Using human lymphocytes as well as an L-selectin-transfected pre-B-cell line in dynamic flow chamber experiments, we could demonstrate that the small-molecule compound efomycine M blocks L-selectin-mediated lymphocyte rolling on sialylated Lewis(X), an action that was confirmed by plasmon resonance spectroscopy. Recruitm...
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ژورنال
عنوان ژورنال: Nature Medicine
سال: 2006
ISSN: 1078-8956,1546-170X
DOI: 10.1038/nm0806-873a