Efficient Synthesis of 1-Sulfonyl-1,2,3-triazoles
نویسندگان
چکیده
منابع مشابه
Rhodium catalyzed diastereoselective synthesis of 2,2,3,3-tetrasubstituted indolines from N-sulfonyl-1,2,3-triazoles and ortho-vinylanilines
An efficient diastereoselective rhodium catalyzed synthesis of indolines possessing two contiguous tetrasubstituted carbon centers has been achieved with good to excellent yields using ortho-vinylanilines and iminocarbenes derived from N-sulfonyl-1,2,3-triazoles. The reaction affords excellent cisdiastereoselectivity through the initial formation of a N-ylide followed by intramolecular trapping...
متن کاملSelective formation of 1,5-substituted sulfonyl triazoles using acetylides and sulfonyl azides.
The reaction of acetylides with sulfonyl azides was found to selectively form 1,5-substituted sulfonyl triazoles. This reaction thus provides access to the regioisomeric product as compared to the popular copper-catalyzed azide-alkyne cycloaddition. The reaction is efficient and selective with a variety of alkyne sources and sulfonyl azides and can incorporate an additional electrophile to yiel...
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New 1,2,4-triazoles (2) having a difluoro(substituted sulfonyl)methyl moiety were designed and synthesized via alpha,alpha-difluoro-alpha-(substituted thio)acetophenones (3). Compounds (2) showed potent antifungal activities against C. albicans, C. krusei, A. flavus and A. fumigatus in vitro and against C. albicans in vivo for oral and i.v. administrations. Especially, (-)-2a, (-)-2b and (-)-2d...
متن کاملSulfonyl-1,2,3-triazoles: convenient synthones for heterocyclic compounds.
1-Sulfonyl-1,2,3-triazoles, which are readily available through copper-catalyzed azide-alkyne cycloaddition, are stable precursors to Rh–azavinyl carbenes, as well as carbene complexes of other metals. Among other transformations, these reactive intermediates can be used for the introduction of a nitrogen atom into various heterocycles that are important in both synthetic and medicinal chemistr...
متن کاملRhodium-catalyzed transannulation of N-sulfonyl-1,2,3-triazoles and epoxides: regioselective synthesis of substituted 3,4-dihydro-2H-1,4-oxazines.
Rhodium-catalyzed transannulation of 1,2,3-triazoles and ring-opening reactions of epoxides is described. A number of 3,4-dihydro-2H-1,4-oxazines are obtained in moderate yields probably involving generation of α-imino rhodium(II) carbene species.
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ژورنال
عنوان ژورنال: Organic Letters
سال: 2010
ISSN: 1523-7060,1523-7052
DOI: 10.1021/ol102087r