Efficient Delivery of GSDMD‐N mRNA by Engineered Extracellular Vesicles Induces Pyroptosis for Enhanced Immunotherapy (Small 20/2023)
نویسندگان
چکیده
Engineered Extracellular Vesicles In article number 2204031, Jing Zhao, Guodong Yang, Angang and co-workers develop an extracellular vesicle-based GSDMD-N mRNA delivery system (EVTx), in which is encapsulated inside the vesicle, HER2 antibody displayed on surface, sonosensitizer Ce6 incorporated into membrane. When endocytosed by HER2+ cancer cells, EVTx efficiently induces pyroptosis thus enhances immunotherapy.
منابع مشابه
Efficient production and enhanced tumor delivery of engineered extracellular vesicles.
Extracellular vesicles (EV), including exosomes and microvesicles, are nano-sized intercellular communication vehicles that participate in a multitude of physiological processes. Due to their biological properties, they are also promising candidates for the systemic delivery of therapeutic compounds, such as cytokines, chemotherapeutic drugs, siRNAs and viral vectors. However, low EV production...
متن کاملExtracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...
متن کاملExtracellular Vesicles as Neprilysin Delivery Syemory Improvement of Alzheimer’s Disease
Alzheimer’s disease (AD) is a neurodegenerative brain disorder which has no effective treatment yet due to the blood barrier in the brain that limits the drugs with the potential of disease improvement. Extracellular vesicles (EVs) are biocompatible nanoparticles with a lipid membrane. These vesicles are secreted from various cells such as mesenchymal stem cells (MSCs) and can pass through biol...
متن کاملLow active loading of cargo into engineered extracellular vesicles results in inefficient miRNA mimic delivery
Extracellular vesicles (EVs) hold great potential as novel systems for nucleic acid delivery due to their natural composition. Our goal was to load EVs with microRNA that are synthesized by the cells that produce the EVs. HEK293T cells were engineered to produce EVs expressing a lysosomal associated membrane, Lamp2a fusion protein. The gene encoding pre-miR-199a was inserted into an artificial ...
متن کاملPhysical exercise induces rapid release of small extracellular vesicles into the circulation
Cells secrete extracellular vesicles (EVs) by default and in response to diverse stimuli for the purpose of cell communication and tissue homeostasis. EVs are present in all body fluids including peripheral blood, and their appearance correlates with specific physiological and pathological conditions. Here, we show that physical activity is associated with the release of nano-sized EVs into the...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Small
سال: 2023
ISSN: ['1613-6829', '1613-6810']
DOI: https://doi.org/10.1002/smll.202370141