منابع مشابه
Efficacy of topiramate.
In controlled clinical trials, topiramate (Topamax) has demonstrated efficacy in refractory patients with complex partial seizures and secondarily generalized tonic-clonic seizures. Approximately 45 percent of 534 patients had a > or = 50 percent reduction in seizure frequency. Limited open label trials have shown that topiramate has broad spectrum activity and may be effective in patients with...
متن کاملEfficacy and Safety of Topiramate for Essential Tremor
Essential tremor (ET) is the most common movement disorder that is frequently treated by propranolol or primidone. However, 30% of patients with ET do not respond to either propranolol or primidone. The objective of this study was to assess the efficacy and safety of topiramate for ET.We searched the MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials for relevant randomized...
متن کاملEfficacy of Topiramate in Migraine Prophylaxis: a Randomized Controlled Study*
Topiramate has been under investigation for the past several years as a prophylactic agent for migraine and other headache disorders. Studies to date have shown it to be safe and effective. As with other antiepileptic drugs, its exact mechanisms of action are not yet known, or at least, the mechanisms that are important in its efficacy in migraine are not yet defined. Topiramate acts on several...
متن کاملEfficacy of topiramate in children with refractory status epilepticus.
PURPOSE Status epilepticus (SE) is a life-threatening medical condition associated with significant morbidity and mortality that requires urgent medical intervention. Although several agents are available to treat SE, they occasionally fail to abort seizure activity. Topiramate (TPM) was anecdotally reported to be effective in adult patients with refractory SE. In this study, we evaluated the e...
متن کاملEfficacy of Zonisamide in Migraineurs with Nonresponse to Topiramate
This study investigated another type of carbonic anhydrase inhibitor and antiepileptic drug, zonisamide, in order to evaluate its potential effectiveness for migraine prophylaxis refractory to topiramate, and to assess intolerability to adverse events, paresthesia in particular. This is an open-labeled retrospective single center study. We included headache patients who met the requirement of m...
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ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1998
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s0317167100034831