Efficacy of Intravitreal Anti Vascular Endothelial Growth Factor Injection Compared to Focal Therapy in Pediatric Patients with Coats Disease

Introduction: Coats disease is a retinal vascular disorder that may lead to progressive exudative detachment. The standard regiment of treatment focal therapy. However, its effectiveness decrease when more than two quadrants the retina exhibit abnormalities. Thus, recent studies tried use anti endothelial growth factor (anti-VEGF) as therapy for problems. Aims: Comparing efficacy between anti-VEGF injection and such laser Methods: Literature searching was conducted through PubMed, ScienceDirect, Google Scholar, ProQuest, SpringerLink. Search terms included "Coats’ Disease" mesh “Anti- VEGF". assessed based on Best-Corrected Visual Acuity (BCVA) improvement in fundus manifestations. Results: All primary intravitreal were followed by necessary ablative treatment. These studies, Yang Q Zheng XX, et al. showed remarkable improvements both visual acuity anatomical outcomes. Laser also gained satisfactory result upgrading clinical stages, even though some complications including subretinal fibrosis, cataract, vitreous hemorrhage reported. A comparative study Ray R, noted group undergoing might require longer sessions despite possible benefits. Conclusion: Anti-VEGF agents can be used neoadjuvant It did not reduce time full treatment, but resolution seen most severe cases treated with combination