Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model
نویسندگان
چکیده
منابع مشابه
Efficacy of Eosin B as a New Antimalarial Drug in a Murine Model
The initial success of any adopted anti-infective strategy to malaria is followed by a descent due to the emergence of resistance to it. The search for new drugs and drug targets is a consistent demand in this disease. Eosin B, a common laboratory dye, is reported to have good antiparasitic properties in vitro. It was studied for its antiparasitic effect in vivo on chloroquine-sensitive Plasmod...
متن کاملEosin B as a novel antimalarial agent for drug-resistant Plasmodium falciparum.
4',5'-Dibromo-2',7'-dinitrofluorescein, a red dye commonly referred to as eosin B, inhibits Toxoplasma gondii in both enzymatic and cell culture studies with a 50% inhibitory concentration (IC(50)) of 180 microM. As a non-active-site inhibitor of the bifunctional T. gondii dihydrofolate reductase-thymidylate synthase (DHFR-TS), eosin B offers a novel mechanism for inhibition of the parasitic fo...
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ژورنال
عنوان ژورنال: Malaria Research and Treatment
سال: 2012
ISSN: 2090-8075,2044-4362
DOI: 10.1155/2012/381724