Efficacy of Deguelin and Silibinin on Benzo(a)pyrene-Induced Lung Tumorigenesis in A/J Mice
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چکیده
منابع مشابه
Chemopreventive effects of deguelin, a novel Akt inhibitor, on tobacco-induced lung tumorigenesis.
Tobacco carcinogens induce Akt activation and lung carcinogenesis. We previously demonstrated that deguelin, a natural plant product, specifically inhibits the proliferation of premalignant and malignant human bronchial epithelial cells by blocking Akt activation. To evaluate the ability of deguelin to block tobacco carcinogen-induced lung tumorigenesis, we evaluated the in vivo effects of degu...
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ownloade pose: Colorectal cancer is the second leading cause of cancer-associated deaths, which suggests ore effort is needed to prevent/control this disease. Herein, for the first time, we investigate the efficacy of silibinin against azoxymethane-induced colon tumorigenesis in A/J mice. erimental Design: Five-week-old male mice were gavaged with vehicle or silibinin (250 and g/kg) for 25 week...
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15 صفحه اولLiposomal encapsulation of deguelin: evidence for enhanced antitumor activity in tobacco carcinogen-induced and oncogenic K-ras-induced lung tumorigenesis.
Deguelin has shown promising chemopreventive and therapeutic activities in diverse types of cancers. However, the potential side effect of deguelin over a certain dose could be the substantial hurdle in the practical application of the drug. One of the successful strategies for the use of deguelin in clinical trials could be lung-specific delivery of the drug. The present study evaluates the ef...
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The gene KRAS is commonly mutated in lung cancer to encode a constitutively active and oncogenic protein that is well established to initiate and maintain lung tumorigenesis. However, the remaining wild-type KRAS protein, or the other family members HRAS and NRAS, can still be activated in the presence of oncogenic KRAS. Moreover, loss of any one of these three genes has been shown to increase ...
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ژورنال
عنوان ژورنال: Neoplasia
سال: 2005
ISSN: 1476-5586
DOI: 10.1593/neo.05532