Efficacy of B Vitamins in Lowering Homocysteine in Older Men
نویسندگان
چکیده
منابع مشابه
Efficacy of B vitamins in lowering homocysteine in older men: maximal effects for those with B12 deficiency and hyperhomocysteinemia.
BACKGROUND AND PURPOSE A higher plasma concentration of total homocysteine (tHcy) is associated with a greater risk of cardiovascular events. Previous studies, largely in younger individuals, have shown that B vitamins lowered tHcy by substantial amounts and that this effect is greater in people with higher tHcy and lower folate levels. METHODS We undertook a 2-year, double-blind, placebo-con...
متن کاملHomocysteine-lowering vitamins do not lower plasma S-adenosylhomocysteine in older people with elevated homocysteine concentrations.
Elevated plasma total homocysteine (tHcy) is a risk factor for vascular disease but lowering tHcy with B-vitamins, including folate, has generally not reduced vascular events in secondary prevention trials. Elevated plasma S-adenosylhomocysteine (AdoHcy) concentration may be a more sensitive indicator of vascular disease than plasma tHcy. However, unlike tHcy, plasma AdoHcy did not correlate wi...
متن کاملHomocysteine Lowering with Folic Acid and B Vitamins in Vascular Disease
The Writing Group (Eva Lonn, M.D., and Salim Yusuf, D.Phil., M.B., B.S., Population Health Research Institute, McMaster University, and the Department of Medicine, Division of Cardiology, Hamilton Health Sciences, Hamilton, Ont.; Malcolm J. Arnold, M.D., Department of Medicine, Division of Cardiology, University of Western Ontario, London; Patrick Sheridan, M.Sc., Janice Pogue, M.Sc., and Mary ...
متن کامل[Homocysteine lowering with folic acid and B vitamins in vascular disease].
BACKGROUND In observational studies, lower homocysteine levels are associated with lower rates of coronary heart disease and stroke. Folic acid and vitamins B6 and B12 lower homocysteine levels. We assessed whether supplementation reduced the risk of major cardiovascular events in patients with vascular disease. METHODS We randomly assigned 5522 patients 55 years of age or older who had vascu...
متن کاملLowering homocysteine with folic acid and B vitamins did not prevent vascular events in vascular disease.
M e t h o d s Design: Randomized placebo-controlled trial (Heart Outcomes Prevention Evaluation [HOPE] 2 trial). Allocation: Concealed.* Blinding: Blinded {clinicians, patients, data collectors, outcome assessors, and data analysts}†.* Follow-up period: Mean 5 years. Setting: 145 centers in 13 countries (Canada, United States, Brazil, western Europe, and Slovakia). Patients: 5522 patients ≥ 55 ...
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ژورنال
عنوان ژورنال: Stroke
سال: 2006
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.0000198815.07315.68