Efficacy of Antimicrobial Lock Solutionsagainst Catheter-Related Infections in Hemodialysis Patients

Antimicrobial lock solutions in the prevention of catheter-related bloodstream infections in patients receiving hemodialysis.

To the Editor—There is increasing evidence that antimicrobial locks applied within the catheter lumen are effective at preventing catheter-related bloodstream infection (CRBSI), a source of substantial morbidity and mortality in patients receiving hemodialysis (HD). Therefore, we read with interest the recently published review article by John Boyce that, in addition to providing a comprehensiv...

Hemodialysis Tunneled Catheter-Related Infections

Catheter-related bloodstream infections, exit-site infections, and tunnel infections are common complications related to hemodialysis central venous catheter use. The various definitions of catheter-related infections are reviewed, and various preventive strategies are discussed. Treatment options, for both empiric and definitive infections, including antibiotic locks and systemic antibiotics, ...

Prevention of Catheter-Related Bloodstream Infections in Patients on Hemodialysis

Fourteen percent of deaths among patients with endstage kidney disease (ESKD) are due to infections, preceded only by cardiovascular diseases (USRDS,2006). According to The United States Renal Data System (USRDS), the number of patients receiving hemodialysis in the United States of America (USA) was 328,000 in 2006(USRDS,2008). Secondary to multiple defects in the ability to kill bacteria, inf...

factors involved in cuffed catheter-related infections in hemodialysis patients

Prevention of hemodialysis catheter-related bloodstream infection using an antimicrobial lock.

Among currently available vascular access options for hemodialysis, central venous catheters show the poorest reliability, with frequent complications of thrombosis and stenosis impairing patency. The most serious problem, however, is catheter-related bloodstream infection (CRBI), which is typically a cause for removal of the catheter and protracted systemic antibiotic therapy. In our experienc...