Efficacy and tolerance of photodynamic therapy with methyl‐aminolevulinic acid in early‐stage mycosis fungoides: A real‐life retrospective study

Abstract Background Methyl‐aminolevulinate‐based photodynamic therapy (MAL‐PDT) has been successfully used in early‐stage mycosis fungoides (MF) lesions. However, the long‐term outcome of initially responding lesions not systematically investigated to date. To address this issue, we hereby report a large series MF treated with MAL‐PDT and followed up for 1 year after initial treatment. Objectives The objective study was retrospectively evaluate short‐ middle‐term clinical results on (patches plaques) identify characteristics possibly predictive effectiveness. Methods Data from all (plaques patches) between 2010 2017 tertiary referral centre were collected. Primary endpoints response rated as complete (CR) or partial (PR), rate relapse further evaluated last PDT session. Secondary addressed tolerance relevancy predefined parameters CR achievement. Results A total 62 30 patients (21 Ia, nine Ib) analysed. At 6‐week evaluation, overall (RR) 87.25% (55% 32.25% PR) mean 2.7 sessions per lesion. Twenty‐five percent relapsed locally within year. Transient, although significant, pain occurred at least once 30% patients. In univariate analysis, location sun‐protected areas only parameter statistically related CR, result confirmed multivariate analysis. Conclusions Overall, these data confirm interest use even deep (folliculotropic) higher efficiency areas. Furthermore, demonstrates first time that is often sustained over time. Accordingly, should be considered management MF, especially oligolesional forms residual refractory systemic