Effects on intermediary metabolism in mouse tissues by Ro-03-8799

Intermediary Metabolism

Intermediary metabolism.

Caenorhabditis elegans has orthologs for most of the key enzymes involved in eukaryotic intermediary metabolism, suggesting that the major metabolic pathways are probably present in this species. We discuss how metabolic patterns and activity change as the worm traverses development and ages, or responds to unfavorable external factors, such as temperature extremes or shortages in food or oxyge...

Universality in intermediary metabolism.

We analyze the stoichiometry, energetics, and reaction concentration dependence of the reductive tricarboxylic acid (rTCA) cycle as a universal and possibly primordial metabolic core. The rTCA reaction sequence is a network-autocatalytic cycle along the relaxation pathway for redox couples in nonequilibrium reducing environments, which provides starting organic compounds for the synthesis of al...

Intermediary metabolism of carbohydrate by Erwinia amylovora.

Erwinia amylovora ferments glucose to yield mainly ethanol, lactate, and carbon dioxide (Sutton and Starr, 1959). The initial steps in the o.xidation of glucose by this bacterium were reported by Katznelson (1955), who later (Katznelson, 1958) showed the presence of certain key enzymes of the Embden-Meyerhof pathway in sonic extracts. The present study, briefly summarized elsewhere (Sutton and ...

Regulation of intermediary metabolism by protein acetylation.

Extensive studies during the past four decades have identified important roles for lysine acetylation in the regulation of nuclear transcription. Recent proteomic analyses on protein acetylation uncovered a large number of acetylated proteins in the cytoplasm and mitochondria, including most enzymes involved in intermediate metabolism. Acetylation regulates metabolic enzymes by multiple mechani...