Effects of Piracetam Supplementation on Cochlear Damage Occuring in Guinea Pigs Exposed to Irradiation
نویسندگان
چکیده
منابع مشابه
L-carnitine reduces cochlear damage induced by gamma irradiation in Guinea pigs.
L-carnitine (LC) protects cells from peroxidative damage. In this study, we tested whether L-carnitine (LC) prevents radiation-induced cochlear damage after total cranial irradiation (radiotherapy; RT). Male albino guinea pigs were randomly distributed in 3 groups. The Control group (n = 11) received neither LC nor irradiation, but saline solution ip and sham irradiation for 5 days. The RT grou...
متن کاملCisplatin effects on guinea pigs: cochlear histology and genotoxicity.
UNLABELLED To understand how the DNA answers to external agents such as cisplatin may be relevant to the diagnosis and treatment of hearing disorders caused by the administration of such drug. OBJECTIVES To investigate the cisplatin influence on the cochlea and DNA of guinea pigs. MATERIAL AND METHODS Experimental study carried out with 12 guinea pigs (Cavia porcellus). The inclusion criter...
متن کاملEffects of Ginkgo biloba extract on the cochlear damage induced by local gentamicin installation in guinea pigs.
Investigations evaluating the protective effect of Ginkgo biloba extract (EGb) on gentamicin (GM) ototoxicity were undertaken. Guinea pigs treated with 5 mg/kg gentamicin sulfate on the round window niche (RWN) showed acute changes on electrocochleogram and hair cell or microvilli damage on scanning electron microscopy (SEM). There was accumulation of GM in the whole cochlea, especially in the ...
متن کاملDifferent Effects of Propofol and Isoflurane on Cochlear Blood Flow and Hearing Function in Guinea Pigs
OBJECTIVES To investigate the effects of isoflurane and propofol on mean arterial pressure (MAP), cochlear blood flow (CoBF), distortion-product otoacoustic emission (DPOAE), and the ultrastructure of outer hair cells (OHCs) in guinea pig cochleae. METHODS Forty-eight male guinea pigs were randomly assigned to one of six treatment groups. Groups 1 to 3 were infused (i.v.) with a loading dose ...
متن کاملInducible nitric oxide synthase participates in cochlear damage after acoustic stimulation in Guinea pigs.
Inducible nitric oxide synthase (iNOS/NOS II) mediates cytotoxicity under pathological stimulation. The purpose of this study was to examine whether the blockade of NOS activity leads to a decrease in cochlear damage after intense acoustic stimulation. Guinea pigs were divided into 4 groups: (1) a noise group, (2) a NOS inhibitor (NG-nitro-L-arginine methyl ester [L-NAME]) + noise gr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 2006
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.29.1460