Effects of α-pinene Administration During Pregnancy on Depressive-like Behavior Following Delivery in Mice

Background: Parturition depression is an important physiological problem, and several attempts have been made to ascertain this phenomenon. Natural monoterpenes like α-pinene numerous beneficial properties, but no studies done on their antidepressant potential in postpartum animals. Objectives: This study aimed determine the effects of prenatal administration antidepressant-like behavior mice following delivery. Methods: Pregnant female were randomly assigned into four groups. In control group, animals injected with saline 5, 8, 11, 14, 17 gestation days (GD). groups 2 4, pregnant (0.1, 0.5, 1 mg/kg, respectively) at GD 17. On day postpartum, open field test (OFT), rotarod, forced swimming (FST), tail suspension (TST) used evaluate activity mice. Also, serum samples taken antioxidant activity. Results: According results, (0.5 mg/kg) significantly increased OFT staying rotarod (P≤0.05). diminished immobility time (s) TST FST decreased malondialdehyde while glutathione peroxidase, superoxide dismutase, total status levels as compared group Conclusion: It seems that can alleviate via its property