effects of hyperbaric oxygen therapy in improvement of Tnf- Α, Hsp 70, Enos, Vegf, collagen 3, and Il 6 protein expression in wound healing

Wound healing is a progressive physiological process with overlapping stages. Hyperbaric oxygen therapy increases tissue oxygenation, thereby increasing oxygenation and the formation of H2O2 as second messenger phosphorylation tumor necrosis factor α, NOS, VEGF, nuclear β-kappa. This further study aims to determine whether hyperbaric can increase collagen 3, HSP 70, IL6 expression wound healing. an animal using "pre-test post-test design randomized control group". Divided into 4 groups (HBO 2.4 ATA 3x30 minutes, 10 sessions HBO group without HBO), each consisted 7 28 male rats. Excision 1x1cm was performed. The distribution data analyzed by SPSS. increased Collagen 3 (p=0.04), 70 (p=0.03), IL 6 (p=0.02) (p=0.002) 5 Collage (p=0.02), L6 significantly but did not improve (p=0, 3) compared HBO.