Effects of histamine and the histamine antagonists mepyramine and cimetidine on human coronary arteries in vitro

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Histamine receptors in the coronary circulation of the dog. Effects of mepyramine and metiamide on responses to histamine infusions.

The effect of histamine on coronary blood flow (CBF) was studied in anaesthetized grayhounds. CBF and systemic blood pressure were measured using electromagnetic flow transducers and catheters in the aorta during infusions of drugs into the left circumflex coronary artery. Histamine infusions (5, 10, and 20 microng/min) produced dose-related increases in CBF without changing heart rate or bloo...

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Histamine and Histamine Antagonists

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ژورنال

عنوان ژورنال: British Journal of Pharmacology

سال: 1983

ISSN: 0007-1188

DOI: 10.1111/j.1476-5381.1983.tb10544.x