Effects of enalapril maleate (MK-421) on renovascular hypertension.

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Hemodynamic and antihypertensive effects of the new oral angiotensin-converting-enzyme inhibitor MK-421 (enalapril).

The antihypertensive, hemodynamic, and humoral effects of the new converting-enzyme inhibitor enalapril (MK-421) were assessed by sequential studies during 3 months of uninterrupted treatment (20 mg twice daily) in 10 hypertensive patients. Six achieved good blood pressure (mean arterial pressure) control with enalapril alone (from 126 +/- 7.0 mm Hg pretreatment to 105 +/- 1.6 mm Hg at 3 months...

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Effects of Short-term Renovascular Hypertension and Type 2 Diabetes on Cardiac Functions in Rats

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The Effects of Enalapril Maleate and Cold Stress on Some Blood Parameters

Enalapril is a highly specific, competitive inhibitor of angiotensin converting enzyme (ACE) belonging to the category of ACE inhibitors. The beneficial effects of ACE inhibitors appear to result primarily the suppression of the plasma renin-angiotensin-aldesteron system. The pharmacological actions of enalapril maleate are related to hypotension. Enalapril maleate is an ACE inhibitor that cont...

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Effects of indomethacin in rabbit renovascular hypertension.

1. Indomethacin inhibits prostaglandin synthesis and interferes with renin release; these effects were studied in rabbit renovascular hypertension. 2. Ten intravenous injections (3 mg day-1 kg-1 after two initial doses of 9 mg/kg) of indomethacin were given daily to ten normal rabbits, ten rabbits with two-kidney Goldblatt hypertension (2KH), tension (1KH). Twelve appropriate control rabbits re...

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Combination treatment of enalapril with nitrendipine in rats with renovascular hypertension.

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ژورنال

عنوان ژورنال: The Tohoku Journal of Experimental Medicine

سال: 1985

ISSN: 0040-8727,1349-3329

DOI: 10.1620/tjem.145.125