Effects of Ecabet Sodium (TA-2711), a New Antiulcer Agent, on Gastrointestinal Mucosal Prostanoid Production and Morphology in Rats.

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Effects of the new anti-ulcer drug ecabet sodium (TA-2711) on pepsin activity. I. Inactivation of enzyme protein.

To investigate the mechanism of the anti-peptic action of ecabet sodium (TA-2711) observed in pylorous-ligated rats, effects of this drug on the peptic activity of rat gastric juice, purified hog pepsin and pepsinogen were studied in vitro. After incubation with or without ecabet at acidic pH, the reaction mixture was centrifuged, and the peptic activity of the supernatant was measured. Ecabet ...

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ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 1993

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.16.1220