Effects of Corynebacterium bovis on Engraftment of Patient-derived Chronic-Myelomonocytic Leukemia Cells in NSGS Mice
نویسندگان
چکیده
منابع مشابه
Engraftment of chronic myelomonocytic leukemia cells in immunocompromised mice supports disease dependency on cytokines.
Chronic myelomonocytic leukemia (CMML) is a clonal hematopoietic stem cell disorder that typically associates with mutations in epigenetic, splicing, and signaling genes. Genetically modified mouse models only partially recapitulate the disease phenotype, whereas xenotransplantation of CMML cells in immunocompromised mice has been rarely successful so far. Here, CMML CD34+ cells sorted from pat...
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We studied the effects ofIL4 on the spontaneous proliferation of chronic myelomonocytic leukemia (CMMoL) cells in vitro. ILA (100 U/ml) suppressed the spontaneous DNA synthesis by 50% in 5 of 8 cases examined. 1L4 (100 U/ml) also inhibited the spontaneous colony formation by CMMoL cells in a methylceliulose culture by 50-97% in all of the 10 cases in which spontaneous colonies were formed. This...
متن کاملExpression of myelomonocytic antigens on chronic lymphocytic leukemia B cells.
We analyzed the expression of myelomonocytic-associated antigens on lymphocytes from B cell chronic lymphocytic leukemia (B-Cu) patients. Blood mononuclear cells were depleted of monocytes by one-step Percoll density gradient centrifugation and tested for antigen expression by fluorescent microscopy and flow cytometry. The reactivity of patient lymphocytes was as follows: 26 of 31 were positive...
متن کاملEffect of IL-27 on activity of bone marrow NK cells of patient with B-chronic lymphocytic leukemia in vitro
Introduction: Functional defect in immune cells is the prominent feature in hematological malignancies that lead to the expansion of tumor cells. Using immunostimulatory cytokines is one of the new therapeutic approaches. This study aimed to investigate the effect of IL-27 on the activity of bone marrow-NK cells of chronic lymphocytic leukemia (CLL) patients in vitro. Materials and Methods: 10 ...
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ژورنال
عنوان ژورنال: Comparative Medicine
سال: 2019
ISSN: 1532-0820
DOI: 10.30802/aalas-cm-18-000138