Effects of Caspofungin against Candida guilliermondii and Candida parapsilosis
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چکیده
منابع مشابه
Effects of caspofungin against Candida guilliermondii and Candida parapsilosis.
The in vitro activity of caspofungin (CAS) was investigated against 28 yeast isolates belonging to Candida albicans (n = 5), Candida guilliermondii (n = 10), and Candida parapsilosis (n = 13). CAS MICs obtained by broth dilution and Etest methods clearly showed a rank order of susceptibility to the echinocandin compound with C. albicans > C. parapsilosis > C. guilliermondii. Similarly, time-kil...
متن کاملComparison of killing activity of caspofungin against Candida parapsilosis, Candida orthopsilosis and Candida metapsilosis.
methods. In the other instance, a BLPAR strain was designated ampicillin-susceptible by Etest (MIC 1⁄4 1 mg/L), ampicillinintermediate by M.I.C.E. (MIC 1⁄4 2 mg/L) and ampicillin-resistant by BMD (MIC 1⁄4 16 mg/L). As stated earlier, the low MICs when gradient methods were used were because of a faint growth within the inhibition zone that was difficult to detect at 24 h. In contrast to the fin...
متن کاملAnti-metabolic activity of caspofungin against Candida albicans and Candida parapsilosis biofilms.
OBJECTIVES Candidiasis can be associated with the formation of biofilms on bioprosthetic surfaces and the intrinsic resistance of Candida albicans biofilms to the most commonly used antifungal agents has been demonstrated. In this study, we report on the antifungal activity of caspofungin at two different concentrations, on C. albicans and Candida parapsilosis biofilms with different ages of ma...
متن کاملCaspofungin in combination with amphotericin B against Candida parapsilosis.
Candida parapsilosis has emerged as an important nosocomial pathogen. In the present study, a checkerboard broth microdilution method was performed to investigate the in vitro activities of caspofungin (CAS) in combination with amphotericin B (AMB) against three clinical isolates of C. parapsilosis. Although there was a significant reduction of the MIC of one or both drugs used in combination, ...
متن کاملKilling kinetics of caspofungin, micafungin, and amphotericin B against Candida guilliermondii.
Amphotericin B (AMB), micafungin, and caspofungin MICs, minimal fungicidal concentrations, and time-killing curves were determined in the presence and absence of 10% inactivated serum. AMB was the only agent with consistent killing activity (time required to achieve 99.9% of growth reduction was 2.1 to 3.2 h). The presence of serum enhanced caspofungin activity but lowered those of micafungin a...
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ژورنال
عنوان ژورنال: Antimicrobial Agents and Chemotherapy
سال: 2006
ISSN: 0066-4804,1098-6596
DOI: 10.1128/aac.00111-06