Effects of beta-glucan in a mice model of vaginitis by candida albicans

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Effects of beta-glucan in a mice model of vaginitis by candida albicans

Methods Fifty four Balb/C mice of 7 to 10 weeks old under influence of estrogen were inoculated with 5x10 stationaryphase blastoconidia of C. albicans, intravaginally. The mice were divided in three groups, treated with glucan vaginally (5mg/mL) and intraperitoneally (1mg/mL), and the control group that received saline, intraperitoneally. Vaginal lavage was obtained on days 2, 5, 8 e 10 after i...

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Evaluation of Candida Vaginitis Epidemic Caused by Candida Albicans in Women of Kazerun City

Introduction: Candida albicans is one of the most common causes of vaginitis and one of the most important reasons for women to visit health centers. The aim of this study was to determine Candida albicans infection and its related factors in women in Kazerun.  Methods: This cross-sectional study was performed in 2017 on 150 samples extracted from the laboratory. Swab specimens were prepared fr...

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Secretory Aspartyl Proteinases Cause Vaginitis and Can Mediate Vaginitis Caused by Candida albicans in Mice

UNLABELLED Vaginal inflammation (vaginitis) is the most common disease caused by the human-pathogenic fungus Candida albicans. Secretory aspartyl proteinases (Sap) are major virulence traits of C. albicans that have been suggested to play a role in vaginitis. To dissect the mechanisms by which Sap play this role, Sap2, a dominantly expressed member of the Sap family and a putative constituent o...

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Murine model of Kawasaki disease induced by mannoprotein-beta-glucan complex, CAWS, obtained from Candida albicans.

Intraperitoneal administration of CAWS (water-soluble extracellular polysaccharide fraction obtained from the culture supernatant of Candida albicans) to mice induces coronary arteritis similar to Kawasaki disease. We analyzed differences in the production of cytokines involved in the occurrence of coronary arteritis among mouse strains, C3H/HeN, C57BL/6, DBA/2 and CBA/J. The incidence of arter...

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Efficacy of ravuconazole in a murine model of vaginitis by Candida albicans.

BACKGROUND The incidence of vulvovaginal candidiasis, a common infection among healthy women primarily caused by the yeast Candida albicans, has increased significantly in recent years. AIMS The purpose of this study was to compare the efficacy of ravuconazole (RVC) and fluconazole (FLC) in the treatment of experimental C. albicans vaginitis. METHODS Forty isolates of C. albicans were scree...

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ژورنال

عنوان ژورنال: World Allergy Organization Journal

سال: 2015

ISSN: 1939-4551

DOI: 10.1186/1939-4551-8-s1-a227