Effects of Allopurinol on 6-Mercaptopurine Therapy in Neoplastic Diseases
نویسندگان
چکیده
منابع مشابه
The effect of 6-mercaptopurine and allopurinol on granulopoiesis.
The effect on granulopoiesis of 6-mercaptopurine alone, and in combination with allopurinol, was studied in mice using an in vitro colony-forming assay for granulocytic progenitor cells. The combination of 6-mercaptopurine and allopurinol pro duced significantly greater suppression of de novo granulo poiesis than did 6-mercaptopurine alone. Allopurinol in very high doses was found to be myelosu...
متن کاملEffect of allopurinol on the pharmacokinetics of 6-mercaptopurine (NSC 755) in cancer patients.
Daily p.o. administration of 300 mg allopurinol to cancer patients almost completely inhibited the production of 6-thiouric acid from i.v. administered 6-mercaptopurine (6-MP) (1000 to 1250 mg). Nonetheless, no effect was observable on the pharmacokinetics of 6-MP in these patients. Applying a two-compartment open model, values for distribution and elimination half-times and inner and outer vol...
متن کاملEffect of allopurinol on clinical outcomes in inflammatory bowel disease nonresponders to azathioprine or 6-mercaptopurine.
BACKGROUND & AIMS Many IBD patients not responding to azathioprine (AZA) or 6-mercaptopurine (6-MP) preferentially metabolize 6-MP to 6-methylmercaptopurine (6-MMP). We describe the use of allopurinol in AZA/6-MP nonresponders to deliberately shunt metabolism of 6-MP toward 6-thioguanine (6-TGN) and improve clinical responses. METHODS Twenty outpatients who were AZA/6-MP nonresponders and had...
متن کاملCombination treatment with 6-mercaptopurine and allopurinol in HepG2 and HEK293 cells – Effects on gene expression levels and thiopurine metabolism
Combination treatment with low-dose thiopurine and allopurinol (AP) has successfully been used in patients with inflammatory bowel disease with a so called skewed thiopurine metabolite profile. In red blood cells in vivo, it reduces the concentration of methylated metabolites and increases the concentration of the phosphorylated ones, which is associated with improved therapeutic efficacy. This...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1966
ISSN: 0003-4967
DOI: 10.1136/ard.25.suppl_6.655