Effects of a Novel Enkephalinase Inhibitor, ONO-9902, on Morphine Antinociception in the Rat Formalin-Test.
نویسندگان
چکیده
منابع مشابه
Antinociceptive effects of ONO-9902, an enkephalinase inhibitor, after visceral stress condition in rats.
PURPOSE The present study was designed to examine the antinociceptive effects of orally administered ONO-9902, an enkephalinase inhibitor, on both somatic and visceral pain after visceral stress conditions. METHODS Twenty six male rats were examined. Tail-flick (TF) and colorectal distension (CD) tests were used to determine somatic and visceral antinociceptive effects, respectively. Measurem...
متن کاملThe Effect of L-NAME on Morphine Antinociception in Formalin Test
Introduction: N- nitro-L-arginine methyl ester (L-NAME), one of the L-arginine analogs, has been specified as an inhibitor of nitric oxide synthase ( NOS).Nitric oxide synthase is an enzyme which leads to nitric oxide synthesis. Since nitric oxide has been known as a pain mediator, it can be said that L-NAME can decrease and relieve pain. In this research the effect of L-NAME on morphine antino...
متن کاملCervicomedullary intrathecal injection of morphine produces antinociception in the orofacial formalin test in the rat.
BACKGROUND High cervical and medullary drug delivery has been advocated for the treatment of refractory head and neck pain in humans. Currently, parallel models in animals have not been developed to support this methodology. We combined an accepted animal model of pain of cranial origin with a novel technique of neuraxial drug delivery to address this issue. METHODS Male Wistar rats were impl...
متن کاملAdditive Antinociception between Intrathecal Sildenafil and Morphine in the Rat Formalin Test
The possible characteristics of spinal interaction between sildenafil (phosphodiesterase 5 inhibitor) and morphine on formalin-induced nociception in rats was examined. Then the role of the opioid receptor in the effect of sildenafil was further investigated. Catheters were inserted into the intrathecal space of male Sprague-Dawley rats. For induction of pain, 50 microL of 5% formalin solution ...
متن کاملThe role of central α-adrenergic receptors on imipramine-induced antinociception as revealed by formalin test in rat
In this study, the effect of α-adrenoceptor agents on imipramine-induced antinociception was investigated using formalin test. Intraperitoneal (i.p.) administration of imipramine at different doses (10-80 mg/kg) induced antinociception in both phases of formalin test. In addition, intracerebroventricular (i.c.v.) injection of imipramine (1, 5, and 10 µg/rat) did not elicit any effect, although ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Japanese Journal of Pharmacology
سال: 1991
ISSN: 0021-5198
DOI: 10.1016/s0021-5198(19)38456-2