Effectiveness of selenium supplementation in children with autoimmune thyroiditis

Deficiencies of Selenium (Se) is correlated with the risk and onset autoimmune thyroid disease (AITD). The aim this study was to determine association between Se supplementation AITD. Methods: Electronic data searches 4 databases were performed. We assessed included studies using PRISMA for protocol assurance. Five met our inclusion criteria analyzed. predictor covariate in present administration. outcome measures levels peroxidase antibodies (TPO-Ab), thyroglobulin antibody (Tg-Ab), free thyroxine (fT4), volume. Results: Of five that criteria, one randomized controlled trial (RCT) qualitative review, whereas four quasi-experimental meta-analysis. results showed significantly reduced TPO-Ab (MD 90.85; 95% CI 61.71–120.00; p<0.00001) fT4 1.52; CI, 0.55–2.50; p=0.002), while RCT Tg-Ab levels. Conclusions: reduces children adolescents limited number population sizes emergence further especially RCTS are needed make a better meta-analysis