Effectiveness of RHZE-FDC (fixed-dose combination) compared to RH-FDC + Z for tuberculosis treatment in Brazil: a cohort study
نویسندگان
چکیده
منابع مشابه
Effectiveness of RHZE-FDC (fixed-dose combination) compared to RH-FDC + Z for tuberculosis treatment in Brazil: a cohort study
BACKGROUND In 2009, Brazil was the sole high-burden country to use three drugs [rifampin (R), isoniazid (H) and pyrazinamide (Z)] as the standard treatment for sensitive tuberculosis, with RH in fixed-dose combination (FDC). In December 2009, the country has adopted the FDC four-drug regimen including ethambutol (E). The rationale was the expectation to reduce default and resistance rates, by i...
متن کاملEffect of fixed-dose combination (FDC) medications on adherence and treatment outcomes
Low adherence to prescribed self‐administered medication is well documented and particularly problematic in the treatment of chronic or asymptomatic conditions1 2. Even in affluent countries with well developed health care infrastructure adherence to long‐term therapy is estimated to average only 50%3. The implications of poor adherence are substantial at both the individual and population lev...
متن کاملEffect of fixed-dose combination (FDC) drugs on development of clinical antimicrobial resistance: a review paper
The emergence of previously unreported infectious diseases, the re‐emergence of infectious disease thought to have been on the way to elimination, and the rapid evolution of infectious pathogens exhibiting antimicrobial resistance (“AMR”) and in particular, multiple‐drug resistance (“MDR”) have created a major clinical and public health threat of global dimensions. The idea that AMR can be del...
متن کاملFactors associated with the rapid implementation process of the fixed-dose combination RHZE tuberculosis regimen in brazil: an ecological study
BACKGROUND The Brazilian National Tuberculosis Control Program (NTCP) recommended the fixed-dose four-drug combination (FDC-RHZE) regimen to treat new tuberculosis cases in December 2009, expecting to increase adherence and avoid resistance. We evaluated factors associated with the speed of the new regimen implementation process in this continent-sized country. METHODS We conducted an ecologi...
متن کاملIn vitro antimicrobial efficacy of a fixed-dose combination of RHZE against M. tuberculosis
The use of drugs in fixed-dose combination (FDC) is now recommended by the World Health Organization (WHO) due to the emergence of multidrug-resistant strains of Mycobacterium tuberculosis. FDC uses different drugs against tuberculosis (TB) in a single tablet for phase-intensive therapeutic intervention. This therapy aims to optimize treatment, to prevent inappropriate use of drugs, and to prev...
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ژورنال
عنوان ژورنال: BMC Infectious Diseases
سال: 2015
ISSN: 1471-2334
DOI: 10.1186/s12879-015-0820-4