Effective model of loop extrusion predicts chromosomal domains
نویسندگان
چکیده
منابع مشابه
Formation of Chromosomal Domains by Loop Extrusion.
Topologically associating domains (TADs) are fundamental structural and functional building blocks of human interphase chromosomes, yet the mechanisms of TAD formation remain unclear. Here, we propose that loop extrusion underlies TAD formation. In this process, cis-acting loop-extruding factors, likely cohesins, form progressively larger loops but stall at TAD boundaries due to interactions wi...
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Expressed Genes in Chromosomal Domains
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متن کاملBIOLOGICAL SCIENCES: Biophysics and Computational Biology Mitotic chromosome compaction via active loop extrusion Short title: Chromosome compaction via loop extrusion
During cell division chromosomes are compacted in length by more than a hundred-fold. A wide range of experiments demonstrated that in their compacted state, mammalian chromosomes form arrays of closely stacked consecutive ~100Kb loops. The mechanism underlying the active process of chromosome compaction into a stack of loops is unknown. Here we test the hypothesis that chromosomes are compacte...
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ژورنال
عنوان ژورنال: Physical Review E
سال: 2020
ISSN: 2470-0045,2470-0053
DOI: 10.1103/physreve.102.032414