Effective immunotherapy against canine visceral leishmaniasis with the FML-vaccine
نویسندگان
چکیده
منابع مشابه
Effective immunotherapy against canine visceral leishmaniasis with the FML-vaccine.
The potential effect of the fucose mannose ligand (FML)-vaccine on immunotherapy of canine visceral leishmaniasis was assayed on five mongrel dogs experimentally infected with Leishmania donovani and on 21 Leishmania chagasi naturally infected dogs when seropositive to FML but completely asymptomatic. The clinical signs of the experimentally infected, symptomatic dogs only disappeared after the...
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[1]. Departamento de Bioquímica, Centro de Biociências, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil. [2]. Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, Rio Grande do Norte, Brasil. [3] Instituto Nacional de Ciências e Tecnologia de Doenças Tropicais, INCT-DT, Salvador, Bahia, Brasil. [4] Departments of Internal Medicine and P...
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CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
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ژورنال
عنوان ژورنال: Vaccine
سال: 2004
ISSN: 0264-410X
DOI: 10.1016/j.vaccine.2003.11.039