Effective gene delivery by using freeze concentration method

Effective in vitro gene delivery to murine cancerous brain cells using carbon nanotube-polyethylenimine conjugates

Objective(s): Carbon nanotube (CNT) has been widely applied at molecular and cellular levels due to its exceptional properties. Studies based on conjugation of CNTs with biological molecules indicated that biological activity is preserved. Polyethylenimine (PEI) is explored in designing novel gene delivery vectors due to its ability to condense plasmid DNA through electrostatic attraction. In t...

formulation and characterization of liposomes containing amphptericin b for topical delivery by freeze drying method

The magnetofection method: using magnetic force to enhance gene delivery.

In order to enhance and target gene delivery we have previously established a novel method, termed magnetofection, which uses magnetic force acting on gene vectors that are associated with magnetic particles. Here we review the benefits, the mechanism and the potential of the method with regard to overcoming physical limitations to gene delivery. Magnetic particle chemistry and physics are disc...

effective in vitro gene delivery to murine cancerous brain cells using carbon nanotube-polyethylenimine conjugates

objective(s): carbon nanotube (cnt) has been widely applied at molecular and cellular levels due to its exceptional properties. studies based on conjugation of cnts with biological molecules indicated that biological activity is preserved. polyethylenimine (pei) is explored in designing novel gene delivery vectors due to its ability to condense plasmid dna through electrostatic attraction. in t...

Classification of Skin Sensitizers on the Basis of Their Effective Concentration 3 Values by Using Adaptive Boosting Method

A new quantitative structure-activity relationship (QSAR) model for the classification of 161 skin sensitizers has been developed with adaptive boosting (Adaboost). The selection of variables for each descriptor was performed with particle swarm optimization (PSO). Among all descriptors in the model, the Radial Distribution Function+3DMolecular Representation of Structure based on Electron diff...