Effective bowel motion reduction in mouse abdominal MRI using hyoscine butylbromide

pharmacotherapy Update: Hyoscine Butylbromide in the Treatment of Abdominal spasms

Abdominal pain is one of the most common reasons why people seek medical care, and is often due to spasm of intra-abdominal visceral organs. Hyoscine butylbromide (HBB) is a quaternary ammonium compound which blocks the action of acetylcholine at parasympathetic sites (both muscarinic and nicotinic receptors) in smooth muscle, and in secretory glands. It causes decreased motility of the gastroi...

Treatment of irritable bowel syndrome with lorazepam, hyoscine butylbromide, and ispaghula husk.

A double-blind controlled therapeutic trial of factorial design was used to study the therapeutic effects of lorazepam, hyoscine butylbromide, and ispaghula husk in 12 randomised blocks of eight patients with the irritable bowel syndrome (IBS). Each of the three agents caused a sustained symptomatic improvement in some of the patients, although only with ispaghula was the difference between the...

Studies on the development of rapidly disintegrating hyoscine butylbromide tablets.

The objective of this study was to prepare hyoscine butylbromide (a drug with bitter taste) tablets that can rapidly disintegrate in saliva. The granules were prepared by the extrusion method using aminoalkyl methacrylate copolymers (Eudragit E-100). The drugs dissolved rapidly in medium at pH 1.2 in a dissolution test while none of the drugs dissolved from the granules (% of dissolved < 5%) ev...

Effect of hyoscine butylbromide on cervical dilation during labor

Angioneurotic oedema and urticaria induced by hyoscine butylbromide.

Case report A 23-year-old white female was admitted to hospital following the sudden onset of swelling of her eyelids, urticarial lesions on her trunk and extremities and a feeling of tightness in her throat. The patient was being treated symptomatically for abdominal colic with hyoscine butylbromide (Buscopan) 10 mg three times a day and had taken one week's supply before the onset of her symp...