Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats
نویسندگان
چکیده
منابع مشابه
Effect of the Combination of CI-988 and Morphine on Neuropathic Pain after Spinal Cord Injury in Rats
Cholecystokinin is known to be involved in the modulation of nociception and to reduce the efficacy of morphine analgesia. This study investigated the effects of intrathecal administration of morphine and the cholecystokinin type B antagonist CI-988 on below-level neuropathic pain after spinal cord injury in rats. We also examined the interaction of morphine and CI-988 in the antinociceptive ef...
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Introduction: Coenzyme Q10 is a powerful antioxidant that has the ability to reduce the damage caused by oxidative stress and is predominantly found in the inner mitochondrial membrane. This study was conducted to determine the effect of coenzyme Q10 on neuropathic pain in an animal model of spinal cord injury. Methods: In order to induce neuropathic pain, thoracic segments of the spinal cor...
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Objectives: The current study evaluated the analgesic effects of bumetanide as an adjunctive in the management of neuropathic pain following spinal cord injury (SCI). The peripheral expression of Na-K-Cl cotransporter-1 (NKCC1) and K-Cl cotransporter-2 (KCC2) genes in polymorphonuclear lymphocytes (PMLs) was assessed as a possible biomarker indicating central mechanisms underlying the observed ...
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ژورنال
عنوان ژورنال: The Korean Journal of Physiology & Pharmacology
سال: 2015
ISSN: 1226-4512,2093-3827
DOI: 10.4196/kjpp.2015.19.2.125