Effect of Sulfanilamide Injected Subcutaneously into Rabbits upon Hemolytic Streptococci Contained in Collodion Sacs Implanted Intraperitoneally

Effect of Sulfanilamide Injected Subcutaneously into Rabbits upon Hemolytic Streptococci Contained in Collodion Sacs Implanted Intraperitoneally.

Experiments were undertaken to determine the effect of sulfanilamide upon hemolytic streptococci growing within the animal body, yet protected by collodion membranes from phagocytosis. The method of manufacturing the collodion sacs used in the experiments has previously been described (Harris, 1939). Theories regarding the r6le of phagocytosis in the drug's action have been amply discussed by L...

The Bactericidal Effect of Sulfanilamide upon Beta Hemolytic Streptococci in Vitro.

The Fate of Avirulent Hemolytic Streptococci Injected into the Skin of Normal and Sensitized Rabbits

1. A relatively avirulent strain of hemolytic streptococci injected into the skin of normal rabbits seldom diminished and usually increased in number during the first 5 hours after inoculation but after 12 hours save in exceptional instances the organisms diminished rapidly and disappeared. 2. Hemolytic streptococci injected into the skin of normal rabbits passed rapidly from the site of inject...

Studies upon Minute Hemolytic Streptococci

1. Minute beta hemolytic streptococci were found to occur from one-third to one-half as frequently in normal individuals as do ordinary beta hemolytic streptococci. 2. They were rarely isolated from the rhinopharynges of individuals suffering from chronic disease. 3. In acute respiratory tract infection other than that due to the ordinary beta hemolytic streptococcus the incidence of minute str...

Reactions of Rabbits to Non-hemolytic Streptococci

1. Accompanying and following the evolution of a secondary reaction in the skin of rabbits after inoculation with suitable doses of certain non-hemolytic streptococci there quickly develops a general state of hypersensitiveness or allergy towards these streptococci. 2. This state is made evident by ophthalmic reactions following corneal inoculations, by much increased reactivity of the skin fol...