Effect of Sodium Alginate Concentration on Characteristics, Stability and Drug Release of Inhalation Quercetin Microspheres

Background: Quercetin is a flavonoid compound that has anti-inflammation activity. However, poor stability presents significant problems for the formulation into dosage forms. Microspheres are one of potential lung delivery systems because their ability to encapsulate various types drugs, protect drugs from environmental effects and can release in sustained release. Objective: In present study, microsphere inhalation system drug, quercetin was developed evaluated achieving targeted these lung. Method: The drug-loaded ca-alginate microspheres were prepared by aerosolization ionic gelation technique followed freeze-drying. Result: result this study showed particle size less than 2 µm, yield ranged 41.33-76.14%, drug loading 6%, entrapment efficiency 74.153% - 93.805% flow properties all formula had an excellent flow. Spherical demonstrated formulations containing 1 1.5% sodium alginate. A highest 30.649% with 2.5% alginate, lowest 26.625% 2% , at temperatures 25ᵒC 40ᵒC 28 days decrease but increase size. alginate optimal formula. Conclusion: These findings indicated be delivered