Effect of Sirolimus on Immune Reconstitution Following Myeloablative Allogeneic Stem Cell Transplantation: An Ancillary Analysis of a Randomized Controlled Trial Comparing Tacrolimus/Sirolimus and Tacrolimus/Methotrexate (Blood and Marrow Transplant Clinical Trials Network/BMT CTN 0402)
نویسندگان
چکیده
منابع مشابه
Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation.
Allogeneic peripheral blood stem cell grafts contain about 10 times more T and B cells than marrow grafts. Because these cells may survive in transplant recipients for a long time, recipients of blood stem cells may be less immunocompromised than recipients of marrow. Immune reconstitution was studied in 115 patients randomly assigned to receive either allogeneic marrow or filgrastim-mobilized ...
متن کاملImpact of Pre-Transplant Anti-T Cell Globulin (ATG) on Immune Recovery after Myeloablative Allogeneic Peripheral Blood Stem Cell Transplantation
BACKGROUND Pre-transplant infusion of rabbit anti-T cell globulin (ATG) is increasingly used as prevention of graft-versus-host disease (GVHD) after allogeneic peripheral blood stem cell transplantation (PBSCT). However, the precise impact of pre-transplant ATG on immune recovery after PBSCT is still poorly documented. METHODS In the current study, we compared immune recovery after myeloablat...
متن کاملCLINICAL TRIALS AND OBSERVATIONS Sirolimus is associated with veno-occlusive disease of the liver after myeloablative allogeneic stem cell transplantation
1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA; 2Blood and Marrow Transplant Clinical Trials Network, Rockville, MD; 3Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA; 4University of Michigan Medical Center, Ann Arbor; 5EMMES Corporation, Rockville, MD; and 6The Center for International Blood and Marrow Transplant Researc...
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Immune reconstitution following stem cell transplantation.
The period of immune deficiency following stem cell transplantation (SCT) results in significant morbidity and mortality. Whilst supportive therapies have partially improved the outcome of infective episodes, disease relapse remains a considerable obstacle to improvement in overall outcomes. An increased understanding of the importance of the immune system in preventing relapse has derived from...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2019
ISSN: 1083-8791
DOI: 10.1016/j.bbmt.2019.06.029