Effect of roseoflavin on microsomal drug-metabolizing enzyme system
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چکیده
منابع مشابه
Effect of administration of 3-aminotriazole on the activity of microsomal drug-metabolizing enzyme systems of rat liver.
protein pigment of microsomes and probably have an important role for the oxidation of drugs (4-10). Recently, Granick and Urata demonstrated that the administration of many drugs, including phenobarbital, markedly increased the activities of 6-amino levu Ionic acid synthetase and synthesis of porphyrine (11, 12). These results suggested that the increase in the activities of drug-metabolizing ...
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This article reports the effect of coexposure to Indian chrysotile asbestos (5 mg/rat) and kerosene soot (5 mg/rat) on the pulmonary phase I and phase II drug-metabolizing enzymes 1, 4, 8, 16, 30, 90, and 150 days after a single intratracheal inoculation. Exposure to soot resulted in a significant induction of the pulmonary microsomal cytochrome P450 and the activity of dependent monooxygenase,...
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1. The effect of chronic enflurane or isoflurane anesthesia on hepatic heme regulation and the drug-metabolizing system in mice treated or not with phenobarbital (PB) was investigated. 2. delta-Aminolevulinic acid synthetase was induced 50-170% in all cases. Urinary porphyrin precursor excretion was also enhanced, but these values were lower when animals also received PB. 3. Cytochrome (CYT) P-...
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‰Á " ¡ —²ˆê Kato et al. (1-3) and Booth and Gillette (4) demonstrated that the sex difference in the activities of drug-metabolizing enzyme systems of rat liver microsomes is related to the anabolic action of male sex hormone. In fact, they demonstrated increases in the activities of drug-metabolizing enzymes of liver microsomes of castrated female rats by the treatment with synthetic hormones ...
متن کاملPhenobarbital-induced Synthesis of the Microsomal Drug-metabolizing Enzyme System and Its Relationship to the Proliferation of Endoplasmic Membranes
Liver microsomes, isolated from rats which had been treated with phenobarbital in vivo, were found to exhibit increased activities of oxidative demethylation and TPNH-cytochrome c reductase and an increased amount of CO-binding pigment. Simultaneous administration of actinomycin D or puromycin abolished the phenobarbital-induced enzyme synthesis. Increased rate of P(i) (32) incorporation into m...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1979
ISSN: 0014-5793
DOI: 10.1016/0014-5793(79)80149-0