EFFECT OF QUARTZETIN TREATMENT ON MALE REPRODUCTIVE FUNCTION UNDER CONDITIONS OF EXPERIMENTAL CHRONIC KIDNEY DISEASE

The aim of the study – to evaluate effect five-fold treatment quercetin on thereproductive function males in mice under conditions experimental chronic kidneydisease (EChKD), namely: 1) number sperm (sperm concentration (million/ml)) andthe abnormal (%)); and provided that such are mated with intactfemales assess: 2) values embryonic mortality before after implantation;3) live fetuses per female mouse.Materials methods. was performed two series experiments maleand EChKD, a model which created by immunizing animals withkidney homogenate.Quercetin (QUR, Sigma, USA) (50 mg / kg) administered intraperitoneally oncedaily, five times according immunization schedule fourth immunization(the last, 3 weeks start experiment).The first is devoted of: (spermconcentration forms sperm.Fertile qualities were evaluated second experiments, afterreplanting them intact females. Pre- post-implantation living mouse have been investigated.Results. QUR does not change sperm, pre- postimplantation newborns (pups) compared tosuch control. kidney disease leads decrease (1.60 times) magnitude(1.37 embryos, as well an increase (1.47 times)in (pups).Conclusions. Quercetin toa embryos,as female.Quercetin may be recommended for correction spermatogenesis clarify new strategies its treatment.