Effect of primary colorectal cancer tumor location on survival after pulmonary metastasectomy

ObjectivesAlthough colorectal cancer bowel segment location has been shown to independently predict the outcomes in early stage disease, it not previously studied setting of pulmonary metastases. We sought determine whether affects survival after metastasectomy.MethodsPatients who had undergone metastasectomy for at a single institution from 2011 2018 were reviewed. Univariable and multivariable Cox regression analyses performed identify predictors overall disease-free survival. The Kaplan-Meier method was used differences between groups.ResultsA total 194 patients evaluated. median follow-up, time, 5-year rate 36.8 months, 75.8 57%, respectively, 122 (63%) experienced disease recurrence any location. On univariable analysis, age, primary tumor location, nodule size, ≥3 nodules, intrathoracic nodal associated with left-sided tumors benefit (hazard ratio, 0.31; P = .036). analysis revealed time 90 months (95% confidence interval, 82 reached) compared 55 49 rectal tumors, (P .078). Location on regression.ConclusionsWe found that is prolonged metastasectomy. Future investigations are required validity such findings, including effect prognostication candidates