Effect of polymyxin B on gram-negative bacterial infection during pregnancy

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Effect of polymyxin B on gram-negative bacterial infection during pregnancy.

OBJECTIVE Polymyxin B (PB) is a naturally occurring cationic cyclic decapeptide which is highly bactericidal to Gram-negative bacteria. The objective of this study was to investigate the effect of PB on the viability of developing embryos during pregnancy and to validate its protective effect on the embryotoxic effect of Gram-negative bacterial lipopolysaccharide (LPS). MATERIAL AND METHODS A...

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Treatment of gram-negative bacteria with lethal doses of polymyxin B and colistin resulted in the formation of projections of the outer layer of the cell wall. Phages T3, T4, and T7, which use wall lipopolysaccharide as receptors, were specifically prevented from adsorbing to Escherichia coli B cells treated with polymyxin, whereas phages T1, T2, T5, and T6 were not. In the systems of phage P22...

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ژورنال

عنوان ژورنال: Journal of the Turkish German Gynecological Association

سال: 2011

ISSN: 1309-0399,1309-0380

DOI: 10.5152/jtgga.2011.17