Effect of phospholipase A2 inhibitors during infection caused by Leishmania (Leishmania) amazonensis

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منابع مشابه

Immune responses induced by the Leishmania (Leishmania) donovani A2 antigen, but not by the LACK antigen, are protective against experimental Leishmania (Leishmania) amazonensis infection.

Leishmania amazonensis is one of the major etiologic agents of a broad spectrum of clinical forms of leishmaniasis and has a wide geographical distribution in the Americas, which overlaps with the areas of transmission of many other Leishmania species. The LACK and A2 antigens are shared by various Leishmania species. A2 was previously shown to induce a potent Th1 immune response and protection...

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Experimental model of chronic osteomyelitis caused by Leishmania (L) amazonensis.

Experimental animal models have been used for the study of the physiopathogenesis of leishmaniasis, on some occasions with success, while in other situations such as bone alterations that accompany tegumentary leishmaniasis, especially in diffuse cutaneous form (DCL), the mechanisms are still unknown. In the present study, we determined these alterations in an animal model susceptible to Leishm...

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Leishmania amazonensis

Resistance to and recovery from leishmania infection is dependent on cell-mediated immunity. C57BL/6 mice are resistant to Leishmania amazonensis (La) infection but susceptible to LP-BM5 murine leukemia virus (MuLV) infection. MuLVinfection leads to a state ofimmunodeficiency characterized by severe compromise ofcell-mediated immunity. When infected with La alone, C57BL/6 mice developed a smaU ...

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Immunomodulatory effect of Canova medication on experimental Leishmania amazonensis infection.

This study investigates the action of Canova medication (CM) on experimental infection by Leishmania (Leishmania) amazonensis, utilizing in vitro and in vivo assays. For the in vitro tests, Balb/c mouse peritoneal macrophages (5x10(5) cells in 500 microl of culture medium, supplemented with 10% fetal calf serum, penicillin (100 U/ml) and streptomycin (0.1 mg/ml) (were distributed in 24-well pla...

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Mixed mucosal leishmaniasis infection caused by Leishmania tropica and Leishmania

26 Mixed infection by different Leishmania species could explain differences in the clinical 27 course of these infections. On identification of Leishmania parasites from Iranian patients 28 with mucosal leishmaniasis (ML), a patient with both oral and nasal lesions was found to be 29 concomitantly infected with L. tropica and L. major. Mixed infection was identified by PCR 30 amplification of ...

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ژورنال

عنوان ژورنال: Journal of Venomous Animals and Toxins including Tropical Diseases

سال: 2018

ISSN: 1678-9199

DOI: 10.1186/s40409-018-0156-9