Effect of nitric oxide donorsS-nitroso-N-acetyl-dl-penicillamine, spermine NONOate and propylamine propylamine NONOate on intracellular pH in cardiomyocytes
نویسندگان
چکیده
منابع مشابه
Pharmacological profile of a nitric oxide donor spermine NONOate in the mouse corpus cavernosum.
BACKGROUND/AIM To investigate the effects of spermine NONOate in the cavernous tissue obtained from mice treated or untreated with sildenafil. MATERIALS AND METHODS We studied the effects of spermine NONOate on the tone and nitrergic relaxation responses of isolated mouse corpus cavernosum and compared them with sodium nitroprusside in the absence or presence of L-nitroarginine, hydroxocobala...
متن کاملEffects of spermine NONOate and ATP on the thermal stability of hemoglobin
BACKGROUND Minor changes in protein structure induced by small organic and inorganic molecules can result in significant metabolic effects. The effects can be even more profound if the molecular players are chemically active and present in the cell in considerable amounts. The aim of our study was to investigate effects of a nitric oxide donor (spermine NONOate), ATP and sodium/potassium enviro...
متن کاملEffects of spermine NONOate and ATP on protein aggregation: light scattering evidences
UNLABELLED BACKGROUND AND OBJECTIVE Regulating protein function in the cell by small molecules, provide a rapid, reversible and tunable tool of metabolic control. However, due to its complexity the issue is poorly studied so far. The effects of small solutes on protein behavior can be studied by examining changes of protein secondary structure, in its hydrodynamic radius as well as its therm...
متن کاملPeroxynitrite and nitric oxide differ in their effects on pig coronary artery smooth muscle.
Peroxynitrite generated in arteries from superoxide and nitric oxide (NO) may damage their function. Here, we compare the effects of peroxynitrite and peroxynitrite/NO-generating agents SIN-1 (3-morpholinosydnonimine hydrochloride), SNAP (S-nitroso-N-acetyl-penicillamine), SNP (sodium nitroprusside), and NONOate (spermine NONOate) on pig coronary artery. Deendothelialized artery rings were pret...
متن کاملStructural Characterization of N,N-Bis(diphenylphosphanyl)propylamine
The synthesis and structural characterization of the Nsubstituted bis(diphenylphosphanyl)amine Ph2PN(R)PPh2 (R = n-propyl, 1) is reported. Single crystals of 1 grown from dichloromethane/acetonitrile have been analyzed by Xray crystallography. The crystallographic study revealed that the diphenylphosphanyl groups in 1 are staggered relative to the PNP backbone as observed for other closely rela...
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ژورنال
عنوان ژورنال: Clinical and Experimental Pharmacology and Physiology
سال: 2012
ISSN: 0305-1870
DOI: 10.1111/j.1440-1681.2012.05734.x