Effect of MDR1 C3435T polymorphism on lansoprazole in healthy Japanese subjects
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چکیده
منابع مشابه
PW01-040 – Definition of polymorphism C3435T MDR1 gene in JIA
Introduction Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic disease in children. Brug of choice is methotrexate (MTX) cytostatic drug from the group of antimetabolites, folic acid antagonists. According to various authors, about 70% of patients receiving therapy with MTX are in remission for the disease. In 1988, MTX was approved FDA (Food and Drug Administration, USA) ...
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BACKGROUND The multidrug resistance gene 1(MDR1) C3435T polymorphism has been reported to be associated with colorectal cancer (CRC) risk in Asians, however the results were inconsistent. Thus, we performed a meta-analysis to generate large-scale evidence on the association between C3435T polymorphism and CRC risk in Asian populations. METHODS The PubMed, Web of Science, Embase, CNKI, and Chi...
متن کاملThe effect of MDR1 C3435T polymorphism on the eradication rate of H. pylori infection in PPI-based triple therapy
BACKGROUND Several studies have reported that multidrug resistance gene 1 (MDR1) C3435T polymorphism was associated with the rate of Helicobacter pylori (H. pylori) eradication in proton pump inhibitor (PPI)-based triple therapy. However, the conclusions were inconsistent. Therefore, this meta-analysis was conducted to evaluate the impact of MDR1 C3435T polymorphism on H. pylori eradication by ...
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INTRODUCTION Considering the high prevalence of liver tumors and the impact on patient survival, a greater understanding of the biological behavior of those tumors if of great importance. The multidrug resistance gene (MDR1) may present as single nucleotide polymorphism (SNP) which can affect the expression and activity of P-glycoprotein (Pgp), and high expression of Pgp has been associated wit...
متن کاملFrequency of the Mdr1 Gene Polymorphism Rs1045642 (c3435t) in Hcv-hiv Co-infected Patients.
Background Due to the high prevalence of co-infection by hepatitis C virus (HCV) and human immunodeficiency virus (HIV) and the severity of these infections, the understanding of the biological mechanisms involved in these processes, including viral behavior and host genetic profile, is of great importance for patient treatment and for public health policies.Some single nucleotide polymorphisms...
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ژورنال
عنوان ژورنال: European Journal of Clinical Pharmacology
سال: 2009
ISSN: 0031-6970,1432-1041
DOI: 10.1007/s00228-009-0625-8