Effect of Mannan Oligosaccharides Extracts in Uropathogenic Escherichia coli Adhesion in Human Bladder Cells

Urinary tract infections (UTIs) are a common public health problem, mainly caused by uropathogenic Escherichia coli (UPEC). Patients with chronic UTIs usually treated long-acting prophylactic antibiotics, which promotes the development of antibiotic-resistant UPEC strains and may complicate their long-term management. D-mannose extracts rich in such as mannan oligosaccharides (MOS; oligomers) promising alternatives to antibiotic prophylaxis due ability inhibit bacterial adhesion urothelial cells and, therefore, infection. This highlights therapeutic potential commercial value using them supplements. Studies on effect MOS are, however, scarce. Aiming evaluate benefits prophylaxis, its mechanism action were assessed. Additionally, expression levels pro-inflammatory marker interleukin 6 (IL-6) also evaluated. After characterizing cytotoxic profiles, preliminary results indicated that have be used for handling demonstrated through they is competitive inhibition FimH adhesins mannose, validated growth impact assessment.