Effect of intra-hippocampal lead injection on affective and cognitive disorders in male WISTAR rats: Possible involvement of oxidative stress

This paper is focused on affective and cognitive disorders induced by direct exposure to lead chloride (Pb) the possible implication of oxidative stress in male WISTAR rats. Using stereotaxic surgery, a group wistar rats received an intracerebral injection 3 μL (1 mg / L) into right hippocampus or 0.9% Nacl for shame operated controls groups. After 4 days rest, series benchmark neurobehavioral tests were made evaluate behaviors, such as open field test (OFT) Elevated plus maze (EPM) anxiety like behavior; Forced swim (FST) depressive finally Y (Y-Maze) Morris (MWM) working memory, spatial learning memory. The data showed that Pb induces anxiogenic depressogenic effects but does not induce significant effect Then measuring markers using hippocampal assay lead-treated rats, it’s appears can increase nitrogen monoxide, lipid peroxidation reduces significantly activity superoxide dismutase. Therefore, our results able highly has insignificant impairment.