Effect of High- and Low-molecular-weight Low-substituted Hydroxyethyl Starch on Blood Coagulation during Acute Normovolemic Hemodilution in Pigs
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چکیده
منابع مشابه
Effect of high- and low-molecular-weight low-substituted hydroxyethyl starch on blood coagulation during acute normovolemic hemodilution in pigs.
BACKGROUND Hydroxyethyl starches (HES) with lower impact on blood coagulation but longer intravascular persistence are of clinical interest. The current study aimed to investigate in vivo the isolated effect of molecular weight on blood coagulation during progressive acute normovolemic hemodilution. METHODS Twenty-four pigs were normovolemically hemodiluted up to a total exchange of 50 ml . k...
متن کاملLow- and medium-molecular-weight hydroxyethyl starches: comparison of their effect on blood coagulation.
BACKGROUND High-molecular-weight hydroxyethyl starch (HES) compromises blood coagulation more than medium-molecular-weight HES. The authors compared medium molecular weight HES (200 kd [HES200]) and low-molecular-weight HES (70 kd [HES70]). METHODS In a prospective, double-blind, randomized-sequence crossover study, 22 male volunteers received 15 ml/kg HES200 and HES70. Blood samples were tak...
متن کاملHemodilution with low-molecular-weight hydroxyethyl starch after experimental focal cerebral ischemia in rabbits.
Newly developed colloid volume-expanding agents with mean molecular weights lower than currently available agents may improve outcome after stroke with fewer allergic and coagulation system side effects. The smaller molecule, however, may exacerbate ischemic cerebral edema if it accumulates in areas where ischemia has damaged the blood-brain barrier. We administered low-molecular-weight hydroxy...
متن کاملDifferential effects of serial hemodilution with hydroxyethyl starch, albumin, and 0.9% saline on whole blood coagulation.
STUDY OBJECTIVES To determine by thrombelastography assessed coagulation, the effects of progressive hemodilution with three intravascular volume expanders. DESIGN Prospective, controlled, whole blood, volumetric ex vivo hemodilution study. SETTING University of Pennsylvania Medical Center Operating Rooms. PATIENTS 60 ASA physical status I and II patients; phlebotomy prior to administrati...
متن کاملEffect of Hemodilution In Vitro with Hydroxyethyl Starch on Hemostasis
BACKGROUND Hydroxyethyl starch (HES) solutions are used for volume expansion during surgery. We aimed to investigate how 6%HES 130/0.4 affects hemostasis. MATERIAL AND METHODS Blood samples were collected from 12 healthy adult volunteers, diluting with 6%HES 130/0.4 (HES group) or Ringer lactate solution (RL control group). The hemodilution ratio (HR) of citrated blood volume to plasma substitu...
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ژورنال
عنوان ژورنال: Anesthesiology
سال: 2006
ISSN: 0003-3022
DOI: 10.1097/00000542-200612000-00023