Effect of Gemfibrozil upon Platelet Function and Blood Coagulation. Preliminary Report
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چکیده
منابع مشابه
Effect of cefamandole nafate on blood coagulation and platelet function.
Platelet function and coagulation were tested after brief in vivo exposure to cefamandole nafate and in the presence of various concentrations of the drug in vitro. Alterations in hemostatic function were observed only with exposure to drug concentrations severalfold higher than those expected to prevail clinically.
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Administration of cephalothin to normal volunteers in maximal doses of 300 mg/kg per day resulted in a combined defect of platelet function and blood coagulation. No such abnormalities were evident after infusion of cefazolin or cephapirin at a maximal dosage of 200 mg/kg per day. The observed thrombocytopathy was similar to but less severe than that induced by carbenicillin or ticarcillin and ...
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Platelet activation and blood coagulation are complementary, mutually dependent processes in haemostasis and thrombosis. Platelets interact with several coagulation factors, while the coagulation product thrombin is a potent platelet-activating agonist. Activated platelets come in a procoagulant state after a prolonged elevation in cytosolic [Ca2+]i. Such platelets, e.g. when adhering to collag...
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Background: Paediatric cardiac surgery has developed dramatically during the last decades. Today, a wide range of patients is operated on-from premature neonates to grown up children with congenital heart disease. Excessive bleeding during and after cardiac surgery is still common, and it is one of the most serious complications. In this thesis, we consider different aspects of monitoring of co...
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By JOHN H. FERGUSON, AARON J. MARCUS AND A. JEAN ROBINSON P LATELET PHOSPHATIDYLSERINE ( PS ) and phosphatidylethanolamine (PE) have been successfully isolated and purified1”8 by applying methods worked out by Rouser and colleagues4 for the corresponding brain phospholipids. With the modern evolution5t of clotting tests, applicable to research on the role of phosphatides7’8 in blood coagulation...
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ژورنال
عنوان ژورنال: Proceedings of the Royal Society of Medicine
سال: 1976
ISSN: 0035-9157
DOI: 10.1177/00359157760690s229