Effect of Fragmentation on Interferon Induction by Double-stranded Virus RNA

Interferon production by double-stranded RNA: a comparison of induction by reovirus to that by a synthetic double-stranded polynucleotide.

Induction of interferon synthesis by synthetic double-stranded polynucleotides.

It has been shown recently that double-stranded ribonucleic acid (RNA) from different sources stimulates the release of interferon into the circulatory system when injected intravenously into rabbits. The same RNA preparations protected mice from viral infections and prevented the viral cytopathic effect in cultures of rabbit kidney cells (A. K. Field et al., Proc. Natl. Acad. Sci. U.S. 58:2102...

Interferon, double-stranded RNA, and protein phosphorylation.

We reported earlier that the addition of double-stranded RNA and ATP increases the endonuclease activity more in an extract of Ehrlich ascites tumor cells which have been treated with an interferon preparation than in a comparable extract from control cells. We report here that the addition of double-stranded RNA to an extract from Ehrlich ascites tumor cells which have been treated with an int...

Blockade of interferon induction and action by the E3L double-stranded RNA binding proteins of vaccinia virus.

The vaccinia virus E3L gene encodes two double-stranded RNA binding proteins that promote viral growth and pathogenesis through suppression of innate immunity. To explore how E3L enables vaccinia virus to evade the interferon system, cells and mice deficient in the principal interferon-regulated antiviral enzymes, PKR and RNase L, were infected with wild-type vaccinia virus and strains of vacci...

Proteins of Vaccinia Virus by the E3L Double-Stranded RNA Binding Blockade of Interferon Induction and Action