Effect of Dose-Rate and Lung Dose in Total Body Irradiation on Interstitial Pneumonitis after Bone Marrow Transplantation
نویسندگان
چکیده
منابع مشابه
Effect of dose-rate and lung dose in total body irradiation on interstitial pneumonitis after bone marrow transplantation.
The aim of this study is to evaluate the incidence of interstitial pneumonitis following fractionated total body irradiation conditioning for bone marrow transplantation with varying lung doses due to shielding technique and different dose-rates. Between 1987 and 2001, a total number of 105 patients have received total body irradiation conditioning for bone marrow transplantation for hematologi...
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Murine bone marrow chimera models were used to assess the efficacy of host total body irradiation (TBI) given at different doses, dose rates, and fractionation schemes in providing for engraftment of syngeneic and allogeneic bone marrow. B6-Hbbd congenic and LP mice, respectively, were used as donors (10(7) bone marrow cells) for syngeneic and allogenic (H-2 compatible) transplantation in stand...
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Total-body irradiation (TBI), when given as part of bone marrow transplantation (BMT), works by enhancing immune suppression and by exerting a tumoricidal effect. The modality has been made less toxic because of new approaches to delivering TBI, such as fractionation, and partial organ shielding, Colleen Lawton, MD, professor at the Medical College of Wisconsin, Milwaukee, said at the 1998 Amer...
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Ninety-nine consecutive patients with acute leukemia in first complete remission under age 50 (median age 27 years; age range 1 to 4 7 years) with a histocompatible sibling donor were treated with fractionated total body irradiation (1,320 cGy) and high-dose etoposide (60 mg/kg) followed by allogeneic bone marrow transplantation. Sixty-one patients were diagnosed with acute myelogenous leukemia...
متن کاملDLA-identical bone marrow grafts after low-dose total body irradiation: effects of high-dose corticosteroids and cyclosporine on engraftment.
Previous studies found that marrow allografts from DLA-identical littermates resulted in survival of 60% of recipient dogs after an otherwise lethal dose of 450 cGy of total body irradiation (TBI), either because of successful allografts or autologous recovery after rejection of the allografts. Forty percent of dogs died with marrow aplasia after allograft rejection. The current study asked whe...
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ژورنال
عنوان ژورنال: The Tohoku Journal of Experimental Medicine
سال: 2004
ISSN: 0040-8727,1349-3329
DOI: 10.1620/tjem.202.255